Outcomes Following Infusion of Insulin Into Ultrasound-Detected Hyperechogenic Tissue in Youth Using Automated
Julian Bjerrekær1, Merete Bechmann Christensen1, Kirsten Nørgaard1
1Copenhagen University Hospital, Steno Diabetes Center Copenhagen, Herlev, Denmark.
Background:
Ultrasound frequently detects hyperechogenic tissue at recent insulin infusion sites in youth using automated insulin delivery, but its short-term clinical significance is unclear.
Methods:
In this post hoc paired analysis of a prior 4-week prospective study, participants were included if they had both hyperechogenic and normoechogenic findings at the most recently used infusion site across 3 visits. Insulin dose and continuous glucose monitoring metrics from days 1 to 2 after infusion-set placement were compared within participants.
Results:
Seventeen participants met the inclusion criteria. Insulin dose and continuous glucose monitoring-derived outcomes did not differ significantly between tissue categories. Time since infusion-set removal differed between categories (1.6 vs 2.1 days, P = .049).
Conclusions:
In this paired analysis, binary ultrasound classification alone did not explain short-term glycemic variation.
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