Related Experiment Video
Updated: Jul 17, 2025
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
16.3K
Relationship between arterial stiffness, left ventricular diastolic function, and renal function in chronic kidney
Balázs Sági1, István Késői2, Tibor Vas1
12nd Dept. of Internal Medicine and Nephrology, Diabetes Centre, Medical School, Clinical Center, University of Pécs, Pacsirta Street 1, Pécs, 7624, Hungary.
BMC Nephrology
|September 3, 2023
Summary
In IgA nephropathy (IgAN), diastolic dysfunction and arterial stiffness worsen with declining kidney function. Early detection of vascular changes in chronic kidney disease (CKD) is possible.
Area of Science:
- Nephrology
- Cardiology
- Vascular Biology
Background:
- Chronic kidney disease (CKD) and IgA nephropathy (IgAN) are associated with adverse cardiovascular outcomes.
- Left ventricular diastolic dysfunction and arterial stiffness are known prognostic indicators in CKD.
- The interplay between diastolic dysfunction, arterial stiffness, and renal function in IgAN requires further elucidation.
Purpose of the Study:
- To investigate the relationship between diastolic dysfunction, arterial stiffness, and renal function in patients with IgA nephropathy.
- To identify early vascular alterations in chronic kidney disease.
Main Methods:
- Seventy-nine IgA nephropathy patients and 50 controls were assessed.
- Diastolic function was measured using Tissue Doppler imaging (Ea, Aa).
- Arterial stiffness was evaluated using stiffness index (SI) and aortic pulse wave velocity (PWVao).
Main Results:
- A significant correlation was observed between diastolic function indices (Ea/Aa) and arterial stiffness measures (SI, PWVao) in IgAN patients.
- Diastolic dysfunction was more prevalent in IgAN patients with advanced CKD (CKD 3-5) compared to those with earlier stages (CKD 1-2).
- Left ventricle rigidity (LVR) correlated with arterial stiffness (SI) and estimated glomerular filtration rate (eGFR), with independent predictors including age, E/A, and E/Ea for SI.
Conclusions:
- Increased cardiac and vascular stiffness are linked to decreased renal function in CKD, directly related to diastolic dysfunction.
- Vascular alterations in early CKD can be identified by comparing CKD patients to controls.
- Arterial stiffness and diastolic dysfunction are significant indicators of renal function decline in IgAN.
Related Concept Videos
01:25Chronic Kidney Disease I: Introduction
34
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
34
01:22Heart Failure Drugs: Diuretics
420
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
420
01:18Chronic Kidney Disease IV: Nursing Management
25
Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
25
01:29Heart Failure II: Pathophysiology
15
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
15
01:29Hypertension II: Pathophysiology
14
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
14
01:24Chronic Kidney Disease II: Clinical Manifestations
29
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
29