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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Relationship between arterial stiffness, left ventricular diastolic function, and renal function in chronic kidney

Balázs Sági1, István Késői2, Tibor Vas1

  • 12nd Dept. of Internal Medicine and Nephrology, Diabetes Centre, Medical School, Clinical Center, University of Pécs, Pacsirta Street 1, Pécs, 7624, Hungary.

BMC Nephrology
|September 3, 2023
PubMed

Insights

In IgA nephropathy (IgAN), diastolic dysfunction and arterial stiffness worsen with declining kidney function. Early detection of vascular changes in chronic kidney disease (CKD) is possible.

Area of Science:

  • Nephrology
  • Cardiology
  • Vascular Biology

Background:

  • Chronic kidney disease (CKD) and IgA nephropathy (IgAN) are associated with adverse cardiovascular outcomes.
  • Left ventricular diastolic dysfunction and arterial stiffness are known prognostic indicators in CKD.
  • The interplay between diastolic dysfunction, arterial stiffness, and renal function in IgAN requires further elucidation.

Purpose of the Study:

  • To investigate the relationship between diastolic dysfunction, arterial stiffness, and renal function in patients with IgA nephropathy.
  • To identify early vascular alterations in chronic kidney disease.

Main Methods:

  • Seventy-nine IgA nephropathy patients and 50 controls were assessed.
  • Diastolic function was measured using Tissue Doppler imaging (Ea, Aa).
  • Arterial stiffness was evaluated using stiffness index (SI) and aortic pulse wave velocity (PWVao).

Main Results:

  • A significant correlation was observed between diastolic function indices (Ea/Aa) and arterial stiffness measures (SI, PWVao) in IgAN patients.
  • Diastolic dysfunction was more prevalent in IgAN patients with advanced CKD (CKD 3-5) compared to those with earlier stages (CKD 1-2).
  • Left ventricle rigidity (LVR) correlated with arterial stiffness (SI) and estimated glomerular filtration rate (eGFR), with independent predictors including age, E/A, and E/Ea for SI.

Conclusions:

  • Increased cardiac and vascular stiffness are linked to decreased renal function in CKD, directly related to diastolic dysfunction.
  • Vascular alterations in early CKD can be identified by comparing CKD patients to controls.
  • Arterial stiffness and diastolic dysfunction are significant indicators of renal function decline in IgAN.
Abstract

Keywords:
Arterial stiffnessChronic kidney diseaseEchocardiography, DopplerIgA nephropathyLeft ventricular diastolic dysfunction

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