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Related Experiment Video

Updated: Jul 17, 2025

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
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Questioning PCOS phenotypes for reclassification and tailored therapy.

Samuel Harry Myers1, Michele Russo1, Simona Dinicola2

  • 1R&D Department, Lo.Li Pharma, 00156 Rome, Italy.

Trends in Endocrinology and Metabolism: TEM
|September 4, 2023
PubMed
Summary

Polycystic Ovary Syndrome (PCOS) diagnosis needs revision. Current criteria overlook metabolic issues like insulin resistance, potentially misdiagnosing patients and hindering effective treatment strategies.

Keywords:
PCOSendocrine-metabolic syndromehyperandrogenisminsulin resistancephenotype D

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Area of Science:

  • Reproductive Endocrinology
  • Metabolic Syndrome
  • Gynecology

Background:

  • Polycystic Ovary Syndrome (PCOS) diagnosis relies on gynecological and endocrinological factors.
  • Patients with PCOS frequently exhibit metabolic impairments, notably insulin resistance, exacerbating symptoms.
  • Existing diagnostic criteria may not fully encompass the spectrum of PCOS manifestations.

Purpose of the Study:

  • To critically evaluate scientific literature questioning the current definition of PCOS.
  • To highlight the limitations of existing diagnostic criteria in addressing metabolic aspects.
  • To advocate for a revision of PCOS diagnostic standards.

Main Methods:

  • Systematic review of scientific reports and opinion pieces.
  • Critical analysis of studies examining PCOS etiology and clinical presentation.
  • Discussion of the implications of metabolic impairments in PCOS diagnosis.

Main Results:

  • Evidence suggests PCOS is a heterogeneous condition with diverse etiological factors.
  • The Rotterdam criteria are increasingly viewed as insufficient and potentially misleading.
  • Metabolic dysfunction, including insulin resistance, is a significant factor often overlooked.

Conclusions:

  • The current definition and diagnostic criteria for PCOS require re-evaluation.
  • A revised approach is needed to incorporate metabolic factors for accurate diagnosis and treatment.
  • The term PCOS may not adequately describe all observed clinical phenotypes.