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Biphasic pleural mesothelioma in a goat
Lindsay M Fry1, Johnathan DenHerder1, Gay Lynn Clyde1
1Animal Disease Research Unit, U.S. Department of Agriculture - Agricultural Research Service, Pullman, Washington 99164, USA (Fry, Schneider); Veterinary Microbiology and Pathology Department (Fry, Williams, Schneider) and Office of the Campus Veterinarian (DenHerder, Clyde), Washington State University, Pullman, Washington 99164, USA.
A rare biphasic pleural mesothelioma was diagnosed in a Saanen goat presenting with thoracic mass symptoms. This finding highlights mesothelioma as a crucial differential diagnosis for thoracic masses in small ruminants.
Area of Science:
- Veterinary Pathology
- Comparative Oncology
- Small Ruminant Medicine
Background:
- Mesothelioma, a rare neoplasm, originates from mesothelial cells lining body cavities.
- Thoracic masses in goats are uncommon, necessitating a broad differential diagnosis list.
- Biphasic mesothelioma contains both epithelial and sarcomatous components.
Observation:
- An 8-year-old Saanen goat presented with anorexia, tachycardia, and cyanosis.
- Physical examination revealed tachypnea, tachycardia, and diminished thoracic auscultation sounds.
- Necropsy identified an infiltrative, multinodular thoracic mass with disseminated pleural nodules.
Findings:
- Histological examination revealed a highly pleomorphic, fusiform to polygonal cell mass.
- Immunohistochemistry showed neoplastic cell positivity for cytokeratin and vimentin.
- Diagnosis confirmed as biphasic pleural mesothelioma based on morphology and immunophenotype.
Implications:
- This case expands the understanding of mesothelioma occurrence in goats.
- Biphasic pleural mesothelioma should be considered in small ruminants with thoracic masses.
- Differential diagnoses for thoracic masses in goats include thymoma, metastatic neoplasia, carcinomatosis, and granulomatous disease.
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