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Progressive Multifocal Encephalopathy Holmes Tremor Successfully Treated with Bilateral Deep Brain Stimulation
Talita D Rosa1, Laura Dixon1, Muhammad Ismail Khalid Yousaf1
1University of Louisville School of Medicine, Department of Neurology, US.
Tremor and Other Hyperkinetic Movements (New York, N.Y.)
|September 4, 2023
Summary
Deep brain stimulation (DBS) effectively treated bilateral Holmes tremor (HT) in an HIV/AIDS patient with progressive multifocal encephalopathy. This first-in-kind bilateral VIM/PSA DBS approach showed no significant side effects and improved tremor control.
Area of Science:
- Neurology
- Neurosurgery
- Infectious Diseases
Background:
- A 58-year-old male with HIV/AIDS and progressive multifocal leukoencephalopathy (PML) experienced a 20-year history of bilateral arm tremor.
- The tremor was refractory to conventional therapies, significantly impacting daily activities.

