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Vitamin D status and blood group among severe COVID-19 patients
Mohamad Aryafar1, Farshid Gholami1, Rama Bozorgmehr2
1Department of Anesthesiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University.
Insights
Vitamin D deficiency was linked to higher mortality in severe COVID-19 patients. However, ABO blood groups did not show a significant correlation with mortality in this study. Further research is recommended.
Area of Science:
- Infectious Diseases
- Endocrinology
- Hematology
Background:
- Prognosis of coronavirus disease 2019 (COVID-19) may be influenced by vitamin D levels and ABO blood groups.
- Previous findings on these associations are inconsistent, necessitating further investigation.
Purpose of the Study:
- To assess the relationship between vitamin D status and ABO blood group systems in patients with severe COVID-19.
- To clarify the impact of these factors on COVID-19 prognosis.
Main Methods:
- A cross-sectional study was conducted on 305 severe COVID-19 patients admitted to intensive care units in Tehran, Iran.
- Serum vitamin D levels and ABO blood group data were collected and statistically analyzed.
Main Results:
- Vitamin D deficiency was significantly associated with increased mortality (P<0.05).
- Blood group O+ was most prevalent (33.1%), followed by A+ (27.8%) and B+ (22.4%).
- No significant correlation was found between ABO blood group and mortality.
Conclusions:
- Mortality in severe COVID-19 patients was significantly linked to vitamin D deficiency, not ABO blood group.
- Further studies with detailed biochemical analyses are recommended to explore these associations.
Objective:
Prognosis of COVID-19 infection has been indicated to be associated with vitamin D status and ABO blood group. However, owing to discrepancies and an increased number of cases globally, the findings remain unclear. This study aimed to evaluate the association between vitamin D and ABO blood group systems in patients with severe COVID-19.
Methods:
In this cross-sectional study, COVID-19 patients referred to two hospitals in the capital of Iran, Tehran, admitted to the ICU ward due to the severity of COVID-19 were evaluated. Serum vitamin D and ABO levels were evaluated in these patients. The data obtained were statistically analyzed using SPSSv24.
Results:
Of 305 patients, 33.1% patients had O+ blood type, 27.8% had A+ blood type and 22.4% had B+ blood type. Vitamin D deficiency was significantly associated with a mortality rate among these patients, P<0.05. The blood group of the patients was not correlated with mortality. Thirty-seven percent of the patients in the study died because of COVID-19.
Conclusion:
In our study population, mortality due to COVID-19 was significantly associated with vitamin D deficiency but not the ABO blood group. We recommend further studies in this regard that include more variable and detailed biochemical analysis.
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