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A Rare Case of Diabetic Nephropathy and Type III Collagen Glomerulopathy
Diana Toro1, Rabia Khan2, Amir Mohammed2
1Internal Medicine, Augusta University Medical College of Georgia, Augusta, USA.
Insights
Collagenofibrotic glomerulopathy, a rare kidney disease, involves abnormal type III collagen in glomeruli. This case shows its co-occurrence with diabetic nephropathy in a young man.
Area of Science:
- Nephrology
- Pathology
- Genetics
Background:
- Collagenofibrotic glomerulopathy (CG) is a rare kidney disease.
- It is characterized by abnormal type III collagen deposition in glomeruli.
- The pathogenesis and clinical presentation of CG are not well understood.
Abstract:
Collagenofibrotic glomerulopathy (CG) is a poorly understood kidney disease characterized by extensive deposition of abnormal type III collagen within the glomeruli. We report the case of a 25-year-old man with known type I diabetes mellitus who presented to the emergency department with diaphoresis, nephrotic-range proteinuria, hypertension, and elevated creatinine. Renal biopsy revealed combined collagenofibrotic glomerulopathy and diabetic nephropathy. This case highlights the clinicopathological features of type III collagen glomerulopathy and its possible association with diabetic nephropathy.
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