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Related Concept Videos

Recycling Endosomes and Transcytosis00:58

Recycling Endosomes and Transcytosis

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The recycling endosome, also known as the endosomal recycling compartment (ERC), is a part of the slow-recycling process of the endocytic pathway. Molecules internalized through receptor-mediated endocytosis are either degraded in the lysosomes or are recycled to the plasma membrane through the fast- or slow-recycling route.
The recycling endosome is not a single organelle but an extensively tubulated network of recycling pathways. It functions in storing molecules or transporting them across...
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ER Retrieval Pathway01:45

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In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
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Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

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Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
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Receptor-mediated Endocytosis01:20

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Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
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The Early Endosome: Endocytosis of Transferrin01:28

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Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
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Directing Proteins to the Rough Endoplasmic Reticulum01:34

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The organelle-specific signaling sequences direct proteins synthesized in the cytosol to their final destination like ER, mitochondria, peroxisomes, etc. Some of the proteins directed to ER are then trafficked via vesicles to other organelles within the cell or the extracellular environment through the Golgi complex. For example, the rough ER synthesizes soluble proteins for transportation to the lysosomes or secretion out of the cell. It can also synthesize transmembrane proteins that can...
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The Microscopy-Based Assay to Study and Analyze the Recycling Endosomes using SNARE Trafficking
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Corrigendum: Small molecules targeting endocytic uptake and recycling pathways.

Giampaolo Placidi1,2, Clara Mattu2, Gianluca Ciardelli2,3

  • 1Italian Institute for Genomic Medicine, Candiolo, Italy.

Frontiers in Cell and Developmental Biology
|September 4, 2023
PubMed
Summary

This study corrects a previous article DOI. The corrected DOI is 10.3389/fcell.2023.1125801, ensuring proper citation and access to the research findings.

Keywords:
endocytic recyclingendocytosisinhibitorsmechanism of actionsmall molecules

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Area of Science:

  • Cellular Biology
  • Biochemistry

Context:

  • Correction of a previously published article DOI.
  • Ensuring accurate referencing and accessibility of scientific literature.

Purpose:

  • To provide the correct Digital Object Identifier (DOI) for the article.
  • To rectify errors in citation information.

Summary:

  • The article DOI has been updated to 10.3389/fcell.2023.1125801.
  • This correction facilitates correct citation and retrieval of the research.

Impact:

  • Improved accuracy in scientific referencing.
  • Enhanced accessibility to the corrected research article for the scientific community.