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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

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Published on: June 21, 2018

Using a chat-based informed consent tool in large-scale genomic research.

Sarah K Savage¹, Jonathan LoTempio², Erica D Smith¹

¹Invitae Corporation, San Francisco, CA, United States.

Journal of the American Medical Informatics Association : JAMIA

|September 4, 2023

Summary

This summary is machine-generated.

A new chatbot consent tool for research studies was found to be efficient and well-understood by participants. This automated approach reduced staff burden without negatively impacting consent rates in a national genomics study.

Keywords:

chatbot genetic counseling genomics informed consent large-scale research

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Area of Science:

Genomics research
Bioinformatics
Clinical trial management

Background:

Participant recruitment and consent are critical steps in large-scale research.
Traditional consent processes can be time-consuming for study staff.
Genomics research requires efficient and scalable participant engagement strategies.

Purpose of the Study:

To implement and evaluate a chatbot consent tool for a national genomics research study.
To assess the efficiency and participant experience of automated consent.
To determine the impact of chatbot consent on consent rates and participant understanding.

Main Methods:

Developed an Institutional Review Board-approved, automated chat-based consent script.
Compared prospective participants using the chatbot tool versus traditional staff-led consent.
Assessed consent completion times, consent rates, and participant understanding via a quiz.

Main Results:

Chat-based consent was completed more quickly than traditional methods.
No significant difference in affirmative consent rates was observed.
Higher completion rates for both affirmative consents and declines were noted with the chatbot.
A high pass rate on the understanding quiz with no adverse events was reported.

Conclusions:

A structured chatbot script effectively conveys essential information for research consent.
Automated consent tools can reduce staff burden and shift time demands.
Chatbots show potential for scaling consent processes in large research projects.