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Correlation of systolic and diastolic blood pressure with echocardiographic phenotypes of cardiac structure and

Julius Nikorowitsch1,2, Ramona Bei der Kellen3, Alena Haack3

  • 1Department of Cardiology, University Heart & Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. j.nikorowitsch@uke.de.

Scientific Reports
|September 4, 2023
PubMed

Insights

High blood pressure, both systolic and diastolic, is linked to early changes in heart structure and function. These findings in large German population studies highlight distinct impacts on the left ventricle, even before heart failure symptoms appear.

Area of Science:

  • Cardiology
  • Cardiovascular Disease Epidemiology
  • Echocardiography

Background:

  • Arterial hypertension is a known risk factor for heart failure development.
  • Early detection of cardiac changes is crucial for preventing heart failure progression.
  • Population-based studies provide insights into cardiovascular health across diverse groups.

Purpose of the Study:

  • To investigate the association between systolic and diastolic blood pressure and early left ventricular (LV) dysfunction.
  • To examine subtle functional and morphological changes in the LV using echocardiography.
  • To analyze these associations across three independent German population cohorts.

Main Methods:

  • Cross-sectional analysis of 26,719 individuals from the Hamburg City Health Study (HCHS), Gutenberg Health Study (GHS), and Study of Health in Pomerania (SHIP).
  • Multivariable linear regression models were used to assess associations between blood pressure and LV parameters.
  • Analyses were adjusted for cardiovascular risk factors and antihypertensive medication.

Main Results:

  • Both systolic and diastolic blood pressure were consistently associated with increased left ventricular hypertrophy.
  • Systolic blood pressure correlated with impaired diastolic function (E/e'), while diastolic blood pressure was linked to reduced systolic function (LVEF).
  • These associations were observed across all three German population cohorts.

Conclusions:

  • Systolic and diastolic blood pressure exhibit differential effects on left ventricular structure and function.
  • Elevated blood pressure is associated with early signs of cardiac remodeling and dysfunction.
  • Findings underscore the importance of blood pressure management in preventing early-stage heart dysfunction.

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