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Updated: Jul 17, 2025

Enabling High Grayscale Resolution Displays and Accurate Response Time Measurements on Conventional Computers
Published on: February 29, 2012
Which resolution?
1Diamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0DE, United Kingdom.
Abstract:
The relationship between the contrast to noise ratio and intensity based cross-correlation coefficients for both protein crystallography and X-ray imaging are compared. It is concluded that, for protein crystallography at near atomic resolution, the intensity based cross-correlation coefficients give a reasonable indication of the quality of the corresponding electron density. For X-ray imaging of biological materials such as cells and soft tissue, the wide range of contrast of the features means that intensity based correlation coefficients can give a poor indication of the interpretability of an image. Rather than the term resolution, it is the contrast to noise ratio for a feature of interest at the relevant spatial frequency that is more relevant. Additional metrics are required to describe the quality of an image, and these are discussed.
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