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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Related Experiment Video

Updated: Jul 17, 2025

Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage
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Finding the Optimal Resistance Training Intensity for Your Bones: Protocol for a Randomized Controlled Trial.

Lora M Giangregorio1,2, Robert R Bleakney3, Sheila Brien4

  • 1Schlegel-UW Research Institute for Aging, University of Waterloo, Waterloo, Ontario, Canada.

Physical Therapy
|September 5, 2023
PubMed
Summary
This summary is machine-generated.

This study compared progressive resistance training (PRT) to a control group for improving bone mineral density (BMD) in older adults. High-intensity PRT may offer greater benefits for bone health and fracture risk reduction.

Keywords:
Bone Mineral DensityFractureIntensityModerateOsteoporosisProgressive Resistance Training

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Area of Science:

  • Gerontology
  • Bone Metabolism
  • Exercise Physiology

Background:

  • Osteoporosis and low bone mineral density (BMD) are significant health concerns in aging populations, increasing fracture risk.
  • Progressive resistance training (PRT) is a potential intervention to improve bone health, but optimal intensity remains under investigation.

Purpose of the Study:

  • To evaluate the 1-year effect of twice-weekly moderate-to-high intensity PRT on lumbar spine BMD in individuals with low BMD.
  • To compare the efficacy of high-intensity versus moderate-intensity PRT and assess other health outcomes, cost-effectiveness, and safety.

Main Methods:

  • A 1-year randomized controlled trial involving 324 adults aged ≥50 years with low BMD or high fracture risk.
  • Participants were randomized to moderate-intensity PRT, high-intensity PRT, or an attention control (posture and balance exercises).
  • Lumbar spine BMD was the primary outcome, with secondary outcomes including bone structure, physical function, falls, fractures, and quality of life.

Main Results:

  • The study is ongoing, and results are pending.
  • Primary outcome is lumbar spine bone mineral density (BMD) measured by dual-energy X-ray absorptiometry.
  • Secondary outcomes encompass bone structure, physical functioning, falls, fractures, metabolic health, and quality of life.

Conclusions:

  • This trial will provide crucial data to inform clinical decisions regarding the optimal intensity of resistance training for individuals at risk of osteoporotic fractures.
  • Findings will guide recommendations for exercise interventions aimed at preserving bone health in aging populations.