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Ultraflexible Neural Probes for Multidirectional Neuronal Activity Recordings over Large Spatial and Temporal Scales.

Yinan Yang1,2,3, Ke Xu1,2,3, Shouliang Guan1

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Nano Letters
|September 5, 2023
PubMed
Summary

New ultraflexible neural probes enable reliable implantation into deep brain regions. These probes allow long-term, multidirectional recordings for neural circuit dissection.

Keywords:
large-scale neural recordingneural interfaceneuronal activity recordingpolymer alloyultraflexible neural probes

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Area of Science:

  • Neuroscience
  • Materials Science
  • Biomedical Engineering

Background:

  • Widespread use of ultraflexible neural probes requires advanced materials for reliable implantation.
  • Deep and difficult-to-access brain regions present significant challenges for current neural probe technologies.

Purpose of the Study:

  • To develop and evaluate ultraflexible neural probes for reliable implantation and long-term neural recordings.
  • To assess the capability of these probes in accessing and recording from deep, anatomically challenging brain regions.

Main Methods:

  • Fabrication of ultraflexible neural probes encapsulated in a biocompatible polymer alloy with controlled dissolution kinetics.
  • In vivo implantation of probes into targeted brain regions, including deep hindbrain areas.
  • Chronic, multidirectional neural recordings from hundreds of neurons across distributed brain regions.

Main Results:

  • Probes were reliably implanted into targeted brain regions over large spatial scales, including deep hindbrain areas.
  • Chronic implantation enabled long-term, multidirectional recordings from hundreds of neurons.
  • Analysis revealed distinct neuronal populations, with 87.0% interneurons in the hindbrain versus 41.9% in the cortex.

Conclusions:

  • Ultraflexible neural probes offer a promising solution for reliable implantation in challenging brain regions.
  • These probes facilitate large-scale, long-term neural circuit dissection.
  • The technology advances the potential for in-depth study of neural circuits in vivo.