Related Experiment Video
Updated: Jul 17, 2025

08:02
Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform
Published on: November 7, 2013
12.9K
Colloidal tubular microrobots for cargo transport and compression.
Xiaoyu Wang1, Brennan Sprinkle2, Hari Krishna Bisoyi3
1Institute of Advanced Materials and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.
Summary
Researchers created complex hollow microtubes from simple colloidal spheres and membranes. These microrobots can be precisely controlled for cargo transport and act as microtweezers, advancing micromachine design.
Area of Science:
- Robotics
- Materials Science
- Biomedical Engineering
Background:
- Microrobot swarms show promise for in vivo applications like drug delivery and imaging.
- Current microrobot swarms are often limited to simple particle aggregates, lacking complex structures.
Purpose of the Study:
- To demonstrate the assembly of complex hollow tubular microrobots from simple colloidal building blocks.
- To explore the controlled propulsion, cargo manipulation, and micro-tool capabilities of these assembled microtubes.
Main Methods:
- Utilizing assembly path design to construct hollow microtubes from isotropic colloidal spheres and colloidal membranes.
- Employing precessing magnetic fields for precise control of microrobot propulsion (direction and velocity).
- Investigating the cargo-carrying capacity and micro-tweezing functionality of the tubular microrobots.
Main Results:
- Successfully assembled complex, hollow microtubes from simple colloidal components.
- Demonstrated stable rolling and precisely controlled locomotion of the microtubes using magnetic fields.
- Showcased the ability of the microtubes to capture, transport, and release cargo, functioning as microtweezers with compressing and uncompressing capabilities.
Conclusions:
- Complex microrobots can be fabricated from simple assemblies, offering a new paradigm for micromachine construction.
- The developed microtubes offer versatile functionalities for in vivo applications, including targeted delivery and manipulation.
- This work provides insights into designing and building sophisticated microrobots from basic building blocks.
Related Concept Videos
Microtubule Associated Motor Proteins
8.1K
Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular...
8.1K
Microtubules
87.6K
There are three types of cytoskeletal structures in eukaryotic cells—microfilaments, intermediate filaments, and microtubules. With a diameter of about 25 nm, microtubules are the thickest of these fibers. Microtubules carry out a variety of functions that include cell structure and support, transport of organelles, cell motility (movement), and the separation of chromosomes during cell division.
87.6K
The Movement of Organelles and Vesicles
4.6K
In eukaryotic cells, cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
4.6K

