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Published on: August 17, 2018
Nickel Catalyzed Carbonylation/Carboxylation Sequence via Double CO2 Incorporation
Riccardo Giovanelli1,2, Lorenzo Lombardi1, Riccardo Pedrazzani1,2
1Dipartimento di Chimica "Giacomo Ciamician", Alma Mater Studiorum - Università di Bologna, Via P. Gobetti 85, 40129, Bologna, Italy.
Abstract:
A carbonylation-carboxylation synthetic sequence, via double CO2 fixation, is described. The productive merger of a Ni-catalyzed cross-electrophile coupling manifold, with the use of AlCl3, triggered a cascade reaction with the formation of three consecutive C-C bonds in a single operation. This strategy traces an unprecedented synthetic route to ketones under Lewis acid assisted carbon dioxide valorization. Computational insights revealed a unique double function of AlCl3, and labeling (13CO2) experiments validate the genuine incorporation of CO2 in both functional groups.
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