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Fabric Moisture Uniform Control to Study the Influence of Air Impingement Parameters on Fabric Drying Characteristics
Published on: August 19, 2019
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Drying capacity of a continuous vibrated fluid bed dryer - Statistical and mechanistic model development
Håkan Wikström1, Luis Martin de Juan2, Johan Remmelgas3
1Early Product Development and Manufacturing, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
International Journal of Pharmaceutics
|September 5, 2023
Summary
Fluid bed dryer performance was optimized by studying process parameters like air temperature and vibration acceleration. Acceleration significantly impacts granule moisture, enabling faster, accurate predictions for enhanced control strategies.
Area of Science:
- Chemical Engineering
- Pharmaceutical Technology
Background:
- Continuous manufacturing processes in pharmaceuticals require precise control over drying operations.
- Fluid bed drying is a critical unit operation for granule moisture reduction.
Purpose of the Study:
- To investigate the drying capacity of a continuous vibrated fluid bed dryer.
- To identify key process parameters influencing granule moisture content.
- To develop predictive models for drying processes.
Main Methods:
- Design of Experiments (DoE) was employed to study microcrystalline cellulose content, water amount, air temperature, air flow rate, and fluid-bed acceleration.
- Wireless sensors were used to measure temperature and humidity profiles.
- Empirical and mechanistic models were formulated.
Main Results:
- Fluid-bed acceleration was identified as the most influential parameter affecting granule moisture content.
- An empirical model provided fast and accurate moisture content prediction.
- A mechanistic model predicted temperature and moisture profiles within the dryer.
Conclusions:
- The developed models can enhance control strategies and optimize continuous drying processes.
- The mechanistic model aids in defining equipment design requirements for specific drying capacities.
- Understanding these parameters is crucial for integrated continuous pharmaceutical manufacturing.
Keywords:
Continuous dryingDigital twinMechanistic modelTwin-screw wet granulationVibrated fluid bed dryerMore Related Videos
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