Interaction between drinking and dietary inflammatory index affects prostate specific antigen: a cross-sectional...

Area of Science:

• Nutrition Science
• Oncology
• Epidemiology

Background:

• The dietary inflammatory index (DII) is linked to adverse health outcomes, but its association with prostate cancer (PCa) is debated.
• Alcohol consumption, a component of DII, has complex health effects and its role in PCa risk is unclear.
• Investigating alcohol's influence on the DII-PCa relationship is crucial for understanding PCa etiology.

Purpose of the Study:

• To evaluate the correlation between the DII and prostate-specific antigen (PSA) levels.
• To clarify whether alcohol consumption modifies the relationship between DII and PCa.
• To assess the DII's utility in predicting PSA levels in different drinking groups.

Main Methods:

• Utilized data from the National Health and Nutrition Examination Survey (NHANES) database (2005-2010).
• Analyzed dietary intake from 4,120 participants to calculate DII scores.
• Employed logistic regression to compare PSA levels between low and high PSA groups, considering alcohol consumption.

Main Results:

• A significant interaction was found between DII, alcohol consumption, and PSA levels (p=0.037).
• The relationship between DII and PSA differed between drinkers (OR: 1.2, 95% CI: 1-1.44) and non-drinkers (OR: 0.98, 95% CI: 0.9-1.07).
• DII and alcohol abstinence were associated with reduced PSA incidence.

Conclusions:

• Alcohol consumption may influence the association between DII and PSA levels.
• DII is a potential indicator for estimating PSA levels in non-drinkers.
• Reducing pro-inflammatory food intake may be beneficial for lowering PCa risk, particularly in non-drinkers.