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Polymorphic Solid Solutions in Molecular Crystals: Tips, Tricks, and Switches.

Adam Hill1,2, Weronika Kras2, Fragkoulis Theodosiou1,2

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Summary
This summary is machine-generated.

Molecular solid solutions are common and impact crystal properties. This study proposes a nomenclature, discusses characterization challenges, and demonstrates how solid solutions alter polymorph stability, using benzamide as a model.

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Area of Science:

  • Crystallography
  • Materials Science
  • Pharmaceutical Science

Background:

  • Crystal polymorphism is crucial in pharmaceuticals, while molecular solid solutions are often overlooked.
  • Molecular compounds frequently contain impurities that form solid solutions, complicating purification.
  • Understanding solid solutions is vital due to their prevalence and impact on crystal properties.

Purpose of the Study:

  • To propose a nomenclature for molecular crystalline solid solutions capable of polymorphism.
  • To highlight challenges in experimental and computational characterization of these systems.
  • To demonstrate the general phenomenon of solid solutions altering polymorph stability.

Main Methods:

  • Development of a novel nomenclature system.
  • Review and discussion of experimental and computational characterization techniques.
  • Experimental investigation of benzamide-based solid solutions with nicotinamide and 3-fluorobenzamide.

Main Results:

  • A new nomenclature system for molecular crystalline solid solutions is proposed.
  • Significant challenges in characterizing these complex systems are identified.
  • Solid solution formation was shown to generally alter the relative stabilities of polymorphs in the benzamide system.

Conclusions:

  • Molecular solid solutions are prevalent and significantly influence crystal behavior.
  • Standardized nomenclature and advanced characterization methods are needed.
  • The impact of solid solutions on polymorph stability is a general phenomenon with implications for drug development.