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Updated: Aug 12, 2026

Generation of Human CD40-activated B cells
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Generation of Human CD40-activated B cells

Published on: October 16, 2009

Reduced responsiveness of immature B cells to the B cell mitogen, lipoprotein

R A Phillips, F Melchers

    Journal of Immunology (Baltimore, Md. : 1950)
    |April 1, 1979
    PubMed

    When pre-B cells are isolated from bone marrow and incubated in vitro for several days, they spontaneously differentiate into LPS-reactive B cells. These newly produced B cells do not respond to another B cell mitogen, lipoprotein (Lp). The lack of Lp reactivity of newly produced B cells represents a qualitative difference between these cells and B cells in peripheral tissues that respond equally well to both LPS and Lp. Thus, responsiveness to different mitogens provides unique markers to identify B cells at early stages of development.

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