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Bempedoic Acid can Reduce Cardiovascular Events in Combination with Statins or As Monotherapy: A Systematic Review

Ju Zhang1, Xiangfeng Guan1, Baixue Zhang1

  • 1School of Clinical Medicine, Affiliated Hospital of Weifang Medical University, Weifang Medical University, Weifang, 261053, People's Republic of China.

American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions
|September 6, 2023
PubMed

Insights

Bempedoic acid significantly reduces major adverse cardiovascular events (MACE), including myocardial infarction and unstable angina hospitalizations. This benefit is observed in patients regardless of statin use, offering a valuable option for cardiovascular risk reduction.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Clinical Trials

Background:

  • Atherosclerotic cardiovascular disease (ASCVD) management is crucial.
  • Bempedoic acid shows promise, but high-quality evidence on clinical event risk reduction is needed.
  • This study evaluates bempedoic acid's impact on cardiovascular event incidence.

Approach:

  • Systematic review and meta-analysis of randomized controlled trials.
  • Searched PubMed, Embase, and Cochrane Central Register up to April 23, 2023.
  • Included four trials comparing bempedoic acid with placebo in 17,323 patients.

Key Points:

  • Bempedoic acid significantly reduced major adverse cardiovascular events (MACE) (RR 0.86).
  • It lowered risks of myocardial infarction (RR 0.76), unstable angina hospitalization (RR 0.70), and coronary revascularization (RR 0.82).
  • MACE risk reduction was consistent in patients on maximally tolerated statin therapy.

Conclusions:

  • Bempedoic acid effectively reduces cardiovascular event risk.
  • The benefits of bempedoic acid are evident irrespective of concomitant statin therapy.
  • This highlights bempedoic acid as a potential therapeutic agent for ASCVD prevention.
Abstract

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