Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Reduced serum carnosinase activity in hypothyroidism.

K Bando, K Ichihara, T Shimotsuji

Annals of Clinical Biochemistry

|March 1, 1986

Summary

Serum carnosinase activity is significantly lower in patients with hypothyroidism, unlike in hyperthyroidism. This finding may aid in diagnosing disorders related to carnosinase deficiency.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Risk factors for fracture by same-level falls among workers across sectors: a cross-sectional study of national open database of the occupational injuries in Japan.

Public health·2023

Same author

Successful live birth in a patient who underwent cranial radiotherapy and systemic chemotherapy by implantation of a cryopreserved blastocyst on day 7.

Clinical and experimental obstetrics & gynecology·2018

Same author

Long-term weight-change slope, weight fluctuation and risk of type 2 diabetes mellitus in middle-aged Japanese men and women: findings of Aichi Workers' Cohort Study.

Nutrition & diabetes·2017

Same author

Sigmoid-vaginal fistula during bevacizumab treatment diagnosed by fistulography.

Journal of clinical pharmacy and therapeutics·2016

Same author

Identification and dynamics of polyglycine II nanocrystals in Argiope trifasciata flagelliform silk.

Scientific reports·2013

Same author

Association of coffee consumption with serum adiponectin, leptin, inflammation and metabolic markers in Japanese workers: a cross-sectional study.

Nutrition & diabetes·2012

Area of Science:

Biochemistry
Endocrinology
Neurology

Background:

Carnosinase enzyme hydrolyzes carnosine in muscle.
Carnosinase deficiency is linked to neuromuscular abnormalities.
Thyroid dysfunction frequently impacts neuromuscular systems.

Purpose of the Study:

To investigate serum carnosinase activity in patients with thyroid dysfunction.
To explore the relationship between carnosinase activity and thyroid hormones.
To assess the clinical relevance in diagnosing carnosinase deficiency disorders.

Main Methods:

Serum carnosinase activity was measured in hyperthyroid, hypothyroid patients, and normal subjects.
Activity levels were compared across groups.
Correlations with serum thyroxine and creatine kinase were analyzed.

Related Experiment Videos

Main Results:

Serum carnosinase activity was not significantly different in hyperthyroidism compared to controls.
Hypothyroidism showed significantly lower carnosinase activity than normal subjects.
In five hypothyroid patients, carnosinase activity normalized after hormone replacement therapy.
Carnosinase activity correlated positively with thyroxine and negatively with creatine kinase in hypothyroidism.

Conclusions:

Serum carnosinase activity is reduced in hypothyroidism.
Carnosinase activity normalization post-therapy supports the link with thyroid function.
This measurement could be valuable for differential diagnosis of carnosinase deficiency.