Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Screening for early diabetic nephropathy.

S M Marshall, K G Alberti

    Annals of Clinical Biochemistry
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Measuring the albumin:creatinine ratio in morning urine samples can effectively screen for microalbuminuria, a key indicator of diabetic nephropathy. This method offers a simpler alternative to traditional urine collection for early detection.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A double blind study of the effect of acipimox on serum lipids, blood glucose control and insulin action in non-obese patients with type 2 diabetes mellitus.

    Diabetic medicine : a journal of the British Diabetic Association·1992
    Same author

    A survey of lower limb amputation in diabetic patients.

    Diabetic medicine : a journal of the British Diabetic Association·1992
    Same author

    Metabolic effects of suppression of nonesterified fatty acid levels with acipimox in obese NIDDM subjects.

    Diabetes·1992
    Same author

    The effects of human proinsulin on glucose turnover and intermediary metabolism in insulin-dependent-diabetes mellitus.

    The Journal of clinical endocrinology and metabolism·1992
    Same author

    Is diabetes always diabetes?

    Diabetes research and clinical practice·1992
    Same author

    Is diabetes mellitus related to undernutrition in rural Tanzania?

    BMJ (Clinical research ed.)·1992

    Area of Science:

    • Nephrology
    • Diabetology
    • Clinical Chemistry

    Background:

    • Diabetic nephropathy is a significant complication of diabetes mellitus.
    • Early detection of diabetic nephropathy is crucial for effective management.
    • Traditional 24-hour urine collection for albumin excretion rate is burdensome.

    Purpose of the Study:

    • To evaluate the utility of the albumin:creatinine ratio (ACR) as a screening tool for microalbuminuria.
    • To determine optimal ACR thresholds for predicting elevated albumin excretion rates (AER).

    Main Methods:

    • Analysis of first morning void urine samples.
    • Measurement of both albumin and creatinine concentrations.
    • Calculation of the albumin:creatinine ratio (ACR).

    Related Experiment Videos

  • Comparison of ACR values with standard albumin excretion rates (AER).

    • Main Results:

    • An ACR threshold above 3.5 demonstrated high sensitivity (98%) but moderate specificity (63%) for AER > 30 µg/min.
    • An ACR threshold above 4.5 showed slightly lower sensitivity (96%) but improved specificity (72%).
    • ACR is a viable screening method for microalbuminuria.

    Conclusions:

    • The albumin:creatinine ratio in a first morning urine sample is a practical initial screening test for microalbuminuria.
    • Further confirmatory testing is necessary to diagnose definite microalbuminuria.
    • ACR offers a less cumbersome alternative to traditional AER measurements for screening purposes.