Strategies to Reverse Hypoxic Tumor Microenvironment for Enhanced Sonodynamic Therapy

Area of Science:

• Biomedical Engineering
• Oncology
• Photodynamic Therapy

Background:

• Sonodynamic therapy (SDT) is effective for malignant tumors due to its noninvasiveness and efficacy.
• Tumor hypoxia often limits SDT's effectiveness by reducing reactive oxygen species generation.
• Hypoxia in solid tumors is a major challenge for traditional oxygen-dependent SDT.

Purpose of the Study:

• To review strategies for alleviating tumor hypoxia to improve SDT efficiency.
• To discuss the principles behind oxygen supply and hypoxia mitigation in SDT.
• To highlight future prospects and clinical considerations for hypoxia-alleviated SDT.

Main Methods:

• Review of existing literature on hypoxia alleviation strategies for SDT.
• Analysis of research examples combining SDT with hypoxia-targeting approaches.
• Discussion of oxygen circulation from consumption to external supply.

Main Results:

• Various strategies exist to increase oxygen supply or prevent hypoxia exacerbation.
• These strategies enhance SDT effectiveness by addressing the hypoxic tumor microenvironment.
• Research examples demonstrate the potential of combined SDT and hypoxia management.

Conclusions:

• Alleviating tumor hypoxia is crucial for optimizing SDT outcomes.
• Future research should focus on efficient oxygen delivery, hypoxia detection, and combination therapies.
• Clinical translation requires careful consideration of these advancements for improved cancer treatment.