Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glutamate carboxypeptidase II activation in astrocytes mediates glymphatic impairment and cognitive vulnerability in the aging brain following surgery.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Neuronal genetic risk within the multicellular landscape of schizophrenia.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Post-weaning social isolation increases reward-seeking behavior in mice.

Physiology & behavior·2026
Same author

BDNF-DT and BDNF-AS-DT: novel genes in the BDNF locus.

Molecular psychiatry·2026
Same author

Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.

Neuron·2026
Same author

Top-down control of sustained attention by medial prefrontal cortex-locus coeruleus (mPFC-LC) projection neurons during the rodent continuous performance test (rCPT).

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026

Related Experiment Video

Updated: Jul 17, 2025

The 5-Choice Serial Reaction Time Task: A Task of Attention and Impulse Control for Rodents
09:43

The 5-Choice Serial Reaction Time Task: A Task of Attention and Impulse Control for Rodents

Published on: August 10, 2014

46.1K

Degrading stimuli by reducing image resolution impairs performance in a rodent continuous performance test.

Adrienne C DeBrosse1, Ye Li1, Robyn Wiseman2

  • 1Lieber Institute for Brain Development, Johns Hopkins University Medical Campus, Baltimore, MD, USA.

Behavioural Processes
|September 6, 2023
PubMed
Summary

Stimulus degradation in rodent continuous performance tests (rCPTs) impairs attention, mirroring human study findings. This research validates reduced image resolution as a translational tool for studying attention deficits.

Keywords:
AttentionBehaviorCognitionReaction time

More Related Videos

Chronic Stress Shifts Effort-Related Choice Behavior in a Y-Maze Barrier Task in Mice
09:37

Chronic Stress Shifts Effort-Related Choice Behavior in a Y-Maze Barrier Task in Mice

Published on: August 13, 2020

11.2K
Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

5.8K

Related Experiment Videos

Last Updated: Jul 17, 2025

The 5-Choice Serial Reaction Time Task: A Task of Attention and Impulse Control for Rodents
09:43

The 5-Choice Serial Reaction Time Task: A Task of Attention and Impulse Control for Rodents

Published on: August 10, 2014

46.1K
Chronic Stress Shifts Effort-Related Choice Behavior in a Y-Maze Barrier Task in Mice
09:37

Chronic Stress Shifts Effort-Related Choice Behavior in a Y-Maze Barrier Task in Mice

Published on: August 13, 2020

11.2K
Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

5.8K

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Animal Models

Background:

  • Attention is crucial for cognitive function and frequently impaired in neuropsychiatric disorders.
  • Continuous Performance Tests (CPTs) are standard clinical tools for assessing attention.
  • Rodent CPTs (rCPTs) offer a translational model for attention research, validated through anatomical and pharmacological studies.

Purpose of the Study:

  • To investigate the effects of stimulus degradation, specifically reduced image resolution, on attention in a touchscreen rodent CPT (rCPT).
  • To determine if reduced image resolution in rCPTs produces behavioral outcomes comparable to human studies.

Main Methods:

  • A touchscreen version of the rodent CPT was employed in mice.
  • Multiple levels of stimulus degradation (reduced image resolution) were systematically tested.
  • Performance metrics included stimulus discrimination, hit reaction time, and reaction time variability.

Main Results:

  • Stimulus degradation significantly impaired attention performance in both male and female mice.
  • Key findings include decreased stimulus discrimination and increased reaction time and variability.
  • These results align with previous human studies on the impact of stimulus degradation in CPTs.

Conclusions:

  • Reduced image resolution serves as a valid method for inducing attention deficits in rCPTs.
  • This study enhances the translational value of rCPTs for studying attention and neuropsychiatric disorders.
  • The findings support the use of stimulus degradation in rCPTs to model human attentional impairments.