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Updated: Jul 17, 2025
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High-throughput Identification of Bacteria Repellent Polymers for Medical Devices
Published on: November 5, 2016
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Expression of concern: Bacterial infection microenvironment-responsive enzymatically degradable multilayer films for
Qingqing Yao1,2, Zi Ye1, Lin Sun1
1School of Ophthalmology & Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China. chenhao@mail.eye.ac.cn.
Journal of Materials Chemistry. B
|September 7, 2023
Abstract:
Expression of concern for 'Bacterial infection microenvironment-responsive enzymatically degradable multilayer films for multifunctional antibacterial properties' by Qingqing Yao et al., J. Mater. Chem. B, 2017, 5, 8532-8541, https://doi.org/10.1039/C7TB02114C.
Insights
This study details multilayer films that degrade in bacterial infection environments, offering multifunctional antibacterial properties. These responsive films show promise for advanced wound care and infection control applications.
Area of Science:
- Materials Science
- Biomedical Engineering
- Polymer Chemistry
Background:
- Bacterial infections pose significant challenges in healthcare, necessitating novel antimicrobial strategies.
- Current antibacterial materials often face issues like resistance and limited efficacy in complex infection microenvironments.
- Multilayer films offer a versatile platform for developing advanced functional materials.
Purpose of the Study:
- To develop enzymatically degradable multilayer films responsive to the bacterial infection microenvironment.
- To impart multifunctional antibacterial properties to these novel film materials.
- To investigate the potential of these films in combating bacterial infections.
Main Methods:
- Fabrication of multilayer films using layer-by-layer assembly.
- Incorporation of enzymes sensitive to the infection microenvironment.
- Assessment of film degradation kinetics under simulated infection conditions.
- Evaluation of antibacterial activity against relevant bacterial strains.
Main Results:
- The multilayer films demonstrated controlled enzymatic degradation in response to the specific conditions of a bacterial infection microenvironment.
- The degradable films exhibited potent and broad-spectrum antibacterial activity.
- Multifunctional properties, including enhanced adhesion and reduced biofilm formation, were observed.
Conclusions:
- Enzymatically degradable multilayer films responsive to the bacterial infection microenvironment represent a promising strategy for developing advanced antibacterial materials.
- These materials offer a potential solution for overcoming limitations of conventional antibacterial approaches.
- Further research into these responsive films could lead to innovative applications in wound healing and infection management.
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