Related Experiment Video
Updated: Jul 17, 2025
09:34
An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
1.9K
Mycobacterium tuberculosis: Pathogenesis and therapeutic targets.
Jiaxing Yang1, Laiying Zhang1, Wenliang Qiao2,3
1Center of Infectious Diseases and State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China.
Medcomm
|September 7, 2023
Summary
Tuberculosis (TB) treatment faces challenges from drug resistance and coinfections. This review explores Mycobacterium tuberculosis infection mechanisms and therapeutic targets, including novel host-directed therapies, for improved drug development.
Area of Science:
- Medical Microbiology
- Immunology
- Pharmacology
Background:
- Tuberculosis (TB) persists as a global health issue, exacerbated by drug resistance, coinfections (e.g., AIDS, COVID-19), and demanding treatment regimens.
- Mycobacterium tuberculosis (Mtb) employs sophisticated mechanisms to adapt to and manipulate host cellular processes during infection.
Purpose of the Study:
- To review the pathogenesis of TB infection, identify key therapeutic targets, and analyze existing and emerging modulators.
- To highlight the potential of host-directed therapy (HDT) as a complementary strategy to conventional antitubercular agents.
Main Methods:
- Comprehensive literature review of TB pathogenesis, therapeutic targets, and drug development.
- Analysis of first-line medications, drugs in clinical trials, and preclinical candidates.
- Evaluation of host-directed therapy approaches targeting immune response and immunopathology.
Main Results:
- Identified critical biological targets within Mtb and host-pathogen interactions.
- Summarized the landscape of current and investigational anti-TB drugs.
- Emphasized the promise of HDT in disrupting Mtb's manipulation of host defenses.
Conclusions:
- Understanding Mtb infection mechanisms and host-pathogen interactions is crucial for innovative TB treatment.
- Host-directed therapies offer a promising avenue to enhance treatment efficacy by bolstering host immunity and mitigating immunopathology.
- This review provides insights for advancing future anti-TB drug discovery and development efforts.
Related Concept Videos
01:28Pulmonary Tuberculosis II
261
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
261
01:28Pulmonary Tuberculosis V
200
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
200
01:31Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
01:29Pulmonary Tuberculosis I
262
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
262
01:26Pulmonary Tuberculosis IV
161
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
161
01:31Pulmonary Tuberculosis III
361
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
361