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Intralymphatic Immunotherapy and Vaccination in Mice
Published on: February 2, 2014
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Innovative delivery systems for epicutaneous immunotherapy.
Zhen Wang1, Lingzhi Wu1, Wei Wang2
1Department of Pharmacy, The First Hospital of Jiaxing, First Affiliated Hospital of Jiaxing University, Jiaxing, China.
Frontiers in Immunology
|September 7, 2023
Summary
Epicutaneous immunotherapy (EPIT) offers a promising, curative approach for allergies by leveraging skin immunity. This review explores EPIT
Area of Science:
- Immunology
- Dermatology
- Allergy Research
Background:
- Allergen-specific immunotherapy (AIT) is the only curative treatment for allergic diseases, aiming to establish peripheral tolerance.
- Conventional subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) show limitations in treating respiratory allergies.
- Epicutaneous immunotherapy (EPIT) is an emerging alternative utilizing skin immunity for allergic disease treatment.
Purpose of the Study:
- To elucidate the immunological mechanisms underlying epicutaneous immunotherapy (EPIT).
- To review innovative delivery systems for allergens and tolerogenic adjuvants in EPIT.
- To discuss the safety, acceptability, and cost-effectiveness of novel EPIT delivery systems.
Main Methods:
- Review of preclinical and clinical studies on epicutaneous immunotherapy (EPIT).
- Analysis of immunological responses modulated by EPIT.
- Evaluation of delivery systems designed to overcome the stratum corneum barrier.
Main Results:
- EPIT demonstrates effectiveness for both respiratory and food allergies in various studies.
- The stratum corneum presents a challenge for allergen delivery, while excessive disruption can induce adverse Th2 responses.
- Innovative systems aim for sufficient allergen and adjuvant delivery while managing skin barrier interactions.
Conclusions:
- EPIT is a promising immunotherapy with potential for curative treatment of allergies.
- Optimized allergen delivery systems are crucial for EPIT's efficacy and safety.
- Further development of EPIT delivery systems should consider safety, patient acceptability, and cost-effectiveness.
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