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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Synthesis and Characterization of Functionalized Metal-organic Frameworks
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Stimuli-Responsive, Dynamic Supramolecular Organic Frameworks.

Alessandro Pedrini1, Danilo Marchetti1,2, Roberta Pinalli1

  • 1Department of Chemistry, Life Sciences and Environmental Sustainability and INSTM UdR Parma, University of Parma, Parco Area delle Scienze 17/A, 43124, Parma, Italy.

Chempluschem
|September 7, 2023
PubMed
Summary
This summary is machine-generated.

Supramolecular organic frameworks (SOFs) are dynamic, crystalline materials built from self-assembled organic blocks. These adaptable SOFs show promise in areas like gas storage, catalysis, and sensing due to their responsive nature.

Keywords:
crystal engineeringnoncovalent interactionsstimuli-responsive materialsstructure-activity relationshipssupramolecular organic frameworks

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Area of Science:

  • Materials Science
  • Supramolecular Chemistry

Background:

  • Supramolecular organic frameworks (SOFs) are 3D materials formed by self-assembly of organic building blocks.
  • Weak interactions like hydrogen bonds, halogen bonds, and π⋅⋅⋅π stacking drive SOF formation.
  • SOFs offer a unique blend of crystallinity and flexibility, enabling dynamic responses to stimuli.

Purpose of the Study:

  • This review focuses on SOFs exhibiting dynamic behavior under various stimuli.
  • It highlights the interplay of building blocks (tectons) and supramolecular interactions in framework assembly.
  • The review explores structure-property relationships and potential applications of dynamic SOFs.

Main Methods:

  • Review of existing literature on supramolecular organic frameworks.
  • Analysis of self-assembly mechanisms driven by non-covalent interactions.
  • Correlation of structural features with observed dynamic properties and applications.

Main Results:

  • SOFs demonstrate tunable dynamic responses to external stimuli (e.g., temperature, light, chemical environment).
  • The choice of organic building blocks and supramolecular interactions dictates the framework's dynamic behavior.
  • Specific examples showcase SOFs for gas storage, separation, catalysis, and sensing.

Conclusions:

  • Dynamic SOFs represent a promising class of intelligent materials with versatile applications.
  • Understanding the fundamental principles of their self-assembly is key to designing advanced functional materials.
  • Further research into SOF dynamics will unlock new possibilities in materials science and beyond.