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[Rapid determination of titanium in human urine by inductively coupled plasma-tandem mass spectrometry]
Miao Zhang1, Zhifei Zhao2, Liang Ding1
1National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Objective:
To establish an inductively coupled plasma-tandem mass spectrometry(ICP-MS/MS) method to determinate the titanium(Ti) in human urine samples rapidly.
Methods:
By comparing different gas mode, ~(47)Ti was selected as the analysis element. Injecting NH_3 to the collision/reaction cell, swept by mass spectrum to determine the optimal mass spectrum conditions with the mass number of Q1=47, Q2=149(Ti ammonia hexamer). The mass spectrometry conditions of internal standard elements, integration time, reaction gas flow rate and data processing method and so on were optimized.
Results:
Ti had a good linear between 0.1-5.00 μg/L under the optimal analytical conditions. The detection limit was 0.1 μg/L. The RSDs of intra-day and inter-day were less than 10%, and the average recoveries were 93.7%-112.2%. The result of Seronorm Trace Elements Urine L-2 met the acceptable range.
Conclusion:
The method is rapid, simple, accuracy, and suitable for the rapid analysis of titanium in human urine.
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