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Assessment and Characterization of Hyaloid Vessels in Mice
Published on: May 15, 2019
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Central posterior hyaloid fibrosis: evolution and outcomes
Ramesh Venkatesh1,2, Ashit Handa3, Vishma Prabhu3
1Dept. of Retina and Vitreous, Narayana Nethralaya, #121/C, 1st R Block, Chord Road, Rajaji Nagar, 560010, Bengaluru, Karnataka, India. vramesh80@yahoo.com.
International Journal of Retina and Vitreous
|September 7, 2023
Summary
Central posterior hyaloid fibrosis (CPHF) is a rare complication of neovascular age-related macular degeneration (nAMD), affecting 6% of patients. CPHF is associated with poor visual outcomes, potentially indicating a profibrotic effect of macular neovascularization on the posterior hyaloid.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Macular Degeneration
Background:
- Central posterior hyaloid fibrosis (CPHF) is a rare condition.
- Neovascular age-related macular degeneration (nAMD) is a leading cause of vision loss.
- Understanding CPHF in nAMD is crucial for patient outcomes.
Purpose of the Study:
- To identify factors contributing to CPHF in nAMD.
- To analyze the clinical outcomes of patients with CPHF and nAMD.
- To investigate the prevalence and impact of CPHF on visual acuity.
Main Methods:
- Retrospective, single-center study.
- Inclusion of patients diagnosed with CPHF and nAMD.
- Analysis of demographic, imaging, anatomical, and functional outcomes.
Main Results:
- CPHF was identified in 6% of patients with chronic scarred macular neovascularization (MNV).
- Type 2 MNV was present in all CPHF eyes; RPE tear in 6%.
- Visual acuity at CPHF identification was poor (mean logMAR 1.498), with no significant change at final follow-up.
Conclusions:
- CPHF is rarely observed in scarred subfoveal type 2 MNVs with subretinal fibrosis.
- CPHF is linked to poor visual outcomes in nAMD.
- The presence of CPHF may suggest a profibrotic role of MNV in the posterior hyaloid.
