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Predictive value of serum βHCG level in ectopic pregnancy: A cross sectional study
Mandana Mansour Ghanaie1, Sanaz Hoshyarmanesh1, Seyedeh Maryam Asgari2
1Department of Obstetrics & Gynecology, Reproductive Health Research Center, Alzahra Hospital, School of Medicine Guilan University of Medical Sciences Rasht Iran.
Health Science Reports
|September 8, 2023
Summary
Serum human chorionic gonadotropin (βHCG) levels can predict successful treatment of tubal ectopic pregnancy (EP) with single-dose methotrexate (SD MTX). A significant decrease in βHCG levels indicates a positive treatment outcome for EP.
Area of Science:
- Reproductive Endocrinology
- Gynecologic Oncology
- Medical Diagnostics
Background:
- Ectopic pregnancy (EP) is a critical condition requiring timely diagnosis and effective treatment.
- Serum βHCG levels are crucial biomarkers in managing EP.
- Evaluating βHCG dynamics post-treatment aids in assessing therapeutic success.
Purpose of the Study:
- To determine the predictive value of serum βHCG levels and their changes following single-dose methotrexate (SD MTX) treatment for tubal EP.
- To identify key βHCG thresholds indicative of successful EP treatment.
- To enhance early diagnosis and management strategies for tubal EP.
Main Methods:
- A cross-sectional study involving 690 women with tubal EP treated with SD MTX.
- Analysis of serum βHCG levels at baseline, day 4, and day 7 post-treatment.
- Statistical analysis using SPSS22, including receiver operating characteristic (ROC) curve analysis.
Main Results:
- SD MTX treatment achieved an 84.7% success rate.
- The successful treatment group showed a 19.53% decrease in βHCG from baseline to day 4, while the failed group had a 12.94% increase (p < 0.001).
- ROC analysis indicated sensitivity of 81% and specificity of 55% for predicting success by day 7, with specific cut-off values.
Conclusions:
- A decrease in serum βHCG levels, particularly a cut-off decrease of 59.9% by day 4 and 81.6% by day 7, effectively predicts successful tubal EP treatment with SD MTX.
- Monitoring βHCG trends is vital for evaluating treatment efficacy in tubal EP.
- These findings support the use of βHCG monitoring for optimizing EP management.
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