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Sex differences in children operated with pyeloplasty for pelvoureteric junction obstruction

Linnea Högberg1, Sanni Värelä2,3, Magnus Anderberg1,2

  • 1Department of Pediatric Surgery, Skåne University Hospital, Lund, Sweden.

Pediatric Surgery International
|September 8, 2023
PubMed

Insights

Boys with pelvoureteric junction obstruction (UPJO) present with pain more often and require reoperation more frequently. Girls with UPJO are more prone to infections, highlighting sex-specific differences in pediatric UPJO management.

Area of Science:

  • Pediatric Urology
  • Pediatric Surgery
  • Nephrology

Background:

  • Pelvoureteric junction obstruction (UPJO) is a common cause of pediatric hydronephrosis.
  • Previous studies have not extensively explored sex-based differences in UPJO presentation and outcomes.

Purpose of the Study:

  • To investigate sex-specific differences in children undergoing pyeloplasty for UPJO.
  • To compare presentation, surgical factors, and long-term results between boys and girls with UPJO.

Main Methods:

  • Retrospective data collection from 194 children who underwent pyeloplasty between 2002 and 2020.
  • Analysis of variables including clinical presentation, surgical approach, and long-term outcomes.

Main Results:

  • No significant differences were observed in prenatal findings, hydronephrosis severity, kidney function, surgical methods, or obstruction types.
  • Boys were more likely to present with pain (47.4% vs 25.0%) and required reoperation (all 9 reoperations were in boys).
  • Girls showed a higher incidence of preoperative infections (17.2% vs 7.0%).

Conclusions:

  • Sex-based differences exist in the presentation and management of pediatric UPJO.
  • Boys with UPJO more frequently present with pain and have a higher reoperation rate.
  • Girls with UPJO are more commonly associated with preoperative infections.
Abstract

Keywords:
Pediatric urologyPyeloplastyReoperationSex differencesUreteropelvic obstruction

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