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Updated: Jul 26, 2026
Multispectral Real-time Fluorescence Imaging for Intraoperative Detection of the Sentinel Lymph Node in Gynecologic Oncology
Published on: October 20, 2010
[Indocyanine green in diagnostics and reconstructive surgery for breast cancer]
A D Zikiryakhodzhaev1,2,3, M V Starkov1, V O Timoshkin1
1Herzen Moscow Oncology Research Institute, Moscow, Russia.
Objective:
To analyze the efficacy of sentinel lymph node detection using indocyanine green (ICG) in breast cancer.
Material And Methods:
The study included 153 breast cancer patients (stage 0-I-II-III, cN0 or cN1-ycN0) between October 2022 and April 2023. All patients underwent sentinel lymph node biopsy using ICG.
Results:
Sentinel lymph node was successfully detected in 150 cases out of 153 ICG injections. Optimal period between ICG injection and its accumulation in regional lymph nodes was 10-12 min. Sensitivity of sentinel lymph node detection was 98.0% that exceeds the approximate value of radioisotope method adopted as a standard (96.9-97.2%), as well as sensitivity of proprietary blue dye (90.6-95.0%). Specificity of this method was 100%.
Conclusion:
The authors' experience regarding application of indocyanine green is consistent with numerous world statistics and proves the possibility of its effective use for sentinel lymph node biopsy. It is necessary to introduce this diagnostic method as a leading or alternative method for analysis of sentinel lymph node in national clinical guidelines.
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