Triglyceride-glucose index and cervical vascular function: outpatient-based cohort study

Area of Science:

• Cardiovascular Research
• Metabolic Syndrome Studies
• Cerebrovascular Health

Background:

• The triglyceride-glucose (TyG) index is a marker of insulin resistance.
• Cervical vascular function is crucial for brain perfusion.
• Understanding factors affecting cervical vasculature is important for public health.

Purpose of the Study:

• To examine the relationship between the TyG index and cervical vascular function.
• To assess this correlation in a general population without prior cerebrovascular disease.

Main Methods:

• A cross-sectional study of 1996 participants without cerebrovascular disease.
• Calculation of TyG index using fasting triglycerides and glucose levels.
• Comparison of vascular parameters between high and low TyG index groups.

Main Results:

• Higher TyG index was associated with lower blood flow velocities (systolic, diastolic, mean) in basilar, vertebral, and internal carotid arteries.
• Increased pulsatility index in the left vertebral and right internal carotid arteries was noted in the high TyG group.
• A significant negative correlation between TyG index and blood flow velocities persisted after adjusting for confounders.

Conclusions:

• A clear correlation exists between the TyG index and cervical vascular function in the general population.
• Elevated TyG index is an independent predictor of reduced cervical vascular blood flow velocity.