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Hyperuricemia as a Risk Factor in Hypertension among Patients with Very High Cardiovascular Risk

Paweł Muszyński1,2, Emil Julian Dąbrowski1, Marta Pasławska3

  • 1Department of Invasive Cardiology, Medical University of Białystok, M. Skłodowskiej-Curie 24A, 15-276 Białystok, Poland.

Healthcare (Basel, Switzerland)
|September 9, 2023
PubMed

Insights

High uric acid levels (over 5 mg/dL) are linked to increased hypertension complications like heart failure and kidney disease in high-risk patients. This suggests uric acid as a potential parallel treatment target.

Area of Science:

  • Cardiology
  • Nephrology
  • Endocrinology

Background:

  • Hypertension is a global health issue and a major risk factor for cardiovascular disease.
  • Current treatments primarily aim to lower blood pressure.
  • Additional factors influencing hypertension complications are sought for targeted therapies.

Purpose of the Study:

  • To investigate the association between serum uric acid concentrations above 5 mg/dL and hypertension complications.
  • To evaluate uric acid's potential role as a parallel treatment target in high-risk populations.

Main Methods:

  • Analysis of 705 patients with hypertension and very high cardiovascular risk.
  • Stratification of patients based on serum uric acid levels.
  • Comparison of complication incidence between groups with uric acid levels > 5 mg/dL and others.

Main Results:

  • Elevated uric acid (> 5 mg/dL) correlated with higher rates of heart failure (OR=1.79), atrial fibrillation (OR=3.45), and chronic kidney disease (OR=2.45).
  • Higher complication rates were also observed in males and individuals with BMI > 25 kg/m².
  • Statistical significance was found for all reported associations (p < 0.003).

Conclusions:

  • Serum uric acid concentrations exceeding 5 mg/dL are associated with increased prevalence of hypertension-related complications.
  • Uric acid may represent a significant factor influencing outcomes in patients with very high cardiovascular risk.
  • These findings support exploring uric acid modulation as a therapeutic strategy.

Keywords:
complicationshypertensionhyperuricemia

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