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Hypertrophic Cardiomyopathy in a Latin American Center: A Single Center Observational Study

Juan David López-Ponce de Leon1,2, Mayra Estacio3, Natalia Giraldo1,2

  • 1Departamento de Cardiología, Fundación Valle del Lili, Cali 760032, Colombia.

Journal of Clinical Medicine
|September 9, 2023
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) is a complex heart condition. This Colombian study of 82 patients highlights its varied presentation, management, and significant morbidity and mortality, offering insights into rare disease care.

Area of Science:

  • Cardiology
  • Genetics
  • Internal Medicine

Background:

  • Hypertrophic cardiomyopathy (HCM) is a rare, complex cardiac disorder with diverse phenotypes and challenges in diagnosis and treatment.
  • Limited data exists on the prevalence and natural history of cardiomyopathies in South America.
  • This study addresses the need for comprehensive data on HCM in a developing country context.

Purpose of the Study:

  • To summarize the clinical features, management strategies, and outcomes of patients with hypertrophic cardiomyopathy (HCM) at a university hospital in Colombia.
  • To provide insights into the characteristics and progression of HCM in a South American population.
  • To contribute data on the management of rare cardiovascular diseases in resource-limited settings.

Main Methods:

  • An observational retrospective cohort study was conducted.
  • Data from 82 patients diagnosed with HCM between January 2010 and December 2021 were analyzed.
  • Information was extracted from an institutional cardiomyopathy registry, including demographic, paraclinical, and outcome data.

Main Results:

  • The cohort comprised 67.1% males, with a mean age at diagnosis of 49 years.
  • Most patients (83%) were in NYHA functional class I or II, with dyspnea being the most common symptom (38%).
  • 89% had preserved left ventricular ejection fraction (LVEF), and 65% showed an asymmetric septal pattern. Interventions included alcohol septal ablation (6%) and septal myectomy (5%). Overall mortality was 7.3%, with sudden cardiovascular death in 2.6%.

Conclusions:

  • Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition associated with considerable morbidity and mortality.
  • This registry offers valuable, comprehensive data on the course and management of HCM in a developing nation.
  • The findings underscore the complexities of managing rare cardiovascular diseases and the need for continued research and improved access to care.
Abstract

Keywords:
cardiomyopathieshypertrophic cardiomyopathy

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