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Semaphorins and Their Roles in Breast Cancer: Implications for Therapy Resistance.
Radhika Aiyappa-Maudsley1, Louis F V McLoughlin1, Thomas A Hughes1,2
1School of Medicine, University of Leeds, Leeds LS9 7TF, UK.
Semaphorins, proteins involved in cell signaling, are linked to breast cancer progression and drug resistance. Understanding their role is crucial for improving treatment outcomes in breast cancer patients.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Breast cancer is a leading cause of cancer-related deaths globally, complicated by disease heterogeneity.
- Semaphorins are proteins with diverse roles, implicated in various human cancers.
- Semaphorins are increasingly recognized for their role in cancer drug resistance.
Purpose of the Study:
- To review the role of semaphorins in breast cancer progression.
- To explore the association between semaphorins and drug resistance in breast cancer.
Main Methods:
- Literature review of studies on semaphorins in breast cancer.
- Analysis of semaphorin involvement in tumor growth, angiogenesis, metastasis, and immune evasion.
- Examination of semaphorin links to resistance against endocrine therapy, taxanes, and anthracyclines.
Main Results:
- Semaphorins are expressed in breast cancer and influence tumor progression.
- Semaphorins are associated with resistance to multiple breast cancer therapies.
- Specific semaphorins contribute to resistance against endocrine therapy and chemotherapy.
Conclusions:
- Semaphorins play a significant role in breast cancer progression and therapeutic resistance.
- Targeting semaphorins may offer novel strategies to overcome drug resistance in breast cancer.
- Further research into semaphorin pathways is warranted for improved breast cancer treatment.
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