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Imprinted Long Non-Coding RNAs in Mammalian Development and Disease
Flavio Di Michele1,2, Isabel Chillón1,2, Robert Feil1,2
1Institute of Molecular Genetics of Montpellier (IGMM), CNRS, 1919 Route de Mende, 34093 Montpellier, France.
International Journal of Molecular Sciences
|September 9, 2023
Summary
Imprinted genes and their long non-coding RNAs (lncRNAs) are vital for development and health. Dysregulation of these crucial lncRNAs can lead to human diseases.
Area of Science:
- Genomics
- Developmental Biology
- Epigenetics
Background:
- Imprinted genes are essential for mammalian development, homeostasis, and disease.
- Most imprinted chromosomal domains express long non-coding RNAs (lncRNAs).
- Imprinted lncRNAs can regulate gene expression in cis and trans.
Purpose of the Study:
- To review the expression and regulatory roles of imprinted lncRNAs.
- To describe human diseases linked to altered imprinted lncRNA expression.
Main Methods:
- Literature review focusing on imprinted lncRNAs.
- Analysis of cis- and trans-regulatory functions.
- Correlation of aberrant expression with human disease syndromes.
Main Results:
- Imprinted lncRNAs are frequently nuclear and control protein-coding gene expression.
- Epigenetic changes in early development can disrupt imprinted lncRNA regulation.
- Perturbed imprinted lncRNA expression is associated with various human diseases.
Conclusions:
- Imprinted lncRNAs have critical roles in gene regulation and development.
- Understanding imprinted lncRNA function is key to deciphering developmental disorders and diseases.
- Further research into epigenetic regulation of imprinted lncRNAs is warranted.
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