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Attenuation of Aging-Related Oxidative Stress Pathways by Phytonutrients: A Computational Systems Biology Analysis

V A Shiva Ayyadurai1, Prabhakar Deonikar1

  • 1Systems Biology Group, CytoSolve Research Division, CytoSolve, Cambridge, MA 02138, USA.

Nutrients
|September 9, 2023
PubMed

Insights

Fruit/berry/vegetable (FBV) juice powder combats aging by reducing oxidative stress. Its bioactive compounds lower reactive oxygen species (ROS) and boost antioxidant enzymes, protecting cellular functions.

Area of Science:

  • Cellular and Molecular Biology
  • Nutritional Science
  • Computational Biology

Background:

  • Aging is linked to cellular damage from oxidative stress, inflammation, and environmental factors.
  • Plant-derived compounds show potential in mitigating oxidative stress damage.
  • Understanding the specific mechanisms of these compounds is crucial for anti-aging strategies.

Purpose of the Study:

  • To investigate the mechanisms by which phytochemicals in fruit/berry/vegetable (FBV) juice powder reduce oxidative stress.
  • To identify key bioactive compounds and their molecular targets.
  • To quantitatively assess the impact of FBV compounds on oxidative stress pathways.

Main Methods:

  • Utilized a computational systems biology approach.
  • Identified major oxidative stress biomolecular pathways.
  • Analyzed phytochemicals in FBV juice powder and their interactions with oxidative stress mechanisms.

Main Results:

  • FBV compounds modulated two key pathways: reactive oxygen species (ROS) production and antioxidant enzyme synthesis.
  • Six specific compounds (cyanidin, delphinidin, ellagic acid, kaempherol, malvidin, rutin) were identified.
  • These compounds significantly decreased ROS production and increased antioxidant enzymes like catalase and superoxide dismutase.

Conclusions:

  • FBV juice powder contains bioactive compounds that effectively attenuate aging.
  • These compounds act on multiple oxidative stress pathways, offering a comprehensive anti-aging effect.
  • The study highlights the potential of FBV-derived phytochemicals in combating age-related cellular damage.
Keywords:
CytoSolveagingantioxidant enzymescomputational systems biologydietary supplementsoxidative stressreactive oxygen species

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