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Updated: Jun 5, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
Molecular systems architecture of host-microbiome interactions in periodontitis
V A Shiva Ayyadurai1, Prabhakar Deonikar1, Philip Stashenko2
1Systems Biology Group, CytoSolve Research Division, CytoSolve, Cambridge, MA.
Objectives:
To develop a systems-level understanding of host-microbial interactions that lead to the pathogenesis of periodontitis. Such an understanding may identify therapeutic targets for developing efficacious treatments for periodontitis.
Search Strategy:
Three databases are searched for relevant peer-reviewed articles published from January 1980 through April 2022.
Citation Sources:
The citation sources include PubMed, MEDLINE, and Google Scholar.
Study Selection Criteria:
The systems biology tool CytoSolve (CytoSolve) was used to perform the systematic review and to support the curation and development of the molecular systems architecture of periodontitis pathogenesis. Full-length articles that contained Medical Subject Headings key words relevant to periodontitis pathogenesis were selected for a comprehensive review.
Data Elements Included:
The molecular interactions across the 8 cell types-gingival epithelial, fibroblast, periodontal ligament, endothelial, keratinocyte, microbial, bone, and immune-of the periodontal microenvironment that leads to the pathogenesis of periodontitis are identified. These interactions are organized into 14 molecular systems involved in periodontitis.
Overall Conclusions:
A molecular systems architecture is developed to provide a visual framework for comprehending the complexity of molecular interactions across the 8 cell types involved in periodontitis pathogenesis. The resulting architecture may be used for target identification and discovery of single and multicombination therapeutics to treat periodontitis more effectively.
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