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Olfactory Receptors: Location and Structure

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...

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Whole Mount Labeling of Cilia in the Main Olfactory System of Mice

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Published on: December 27, 2014

Target-Captured mRNA from Murine Olfactory Bulb.

Kevin W Zhu¹, Hiroaki Matsunami^1,2

¹Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.

Methods in Molecular Biology (Clifton, N.J.)

|September 9, 2023

Summary

This summary is machine-generated.

Researchers mapped olfactory receptors (ORs) in the mouse olfactory bulb (OB) using a novel spatial transcriptomics method. This technique successfully mapped 86% of ORs, revealing a link between receptor sequence and glomerular position.

Keywords:

Gene expression analysis Olfactory bulb Olfactory receptor RNA sequencing

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Imaging Odor-Evoked Activities in the Mouse Olfactory Bulb using Optical Reflectance and Autofluorescence Signals

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Published on: October 31, 2011

Area of Science:

Neuroscience
Genomics
Sensory Systems Biology

Background:

Olfaction relies on organized sensory receptor systems, with olfactory processing centered in the olfactory bulb (OB) glomeruli.
Understanding the mapping of olfactory receptors (ORs) to glomeruli is key to deciphering the olfactory system's architecture and function.

Purpose of the Study:

To develop and apply a method for enriching low-abundant OR messenger RNAs (mRNAs) from the mouse OB.
To generate high-throughput spatial mapping of ORs to glomeruli within the OB.

Main Methods:

Combined sequential sectioning (anteroposterior, dorsoventral, mediolateral axes) with target capture enrichment sequencing.
Overcame challenges of low-abundance target gene expression for accurate mapping.

Main Results:

Spatially mapped 86% of olfactory receptors across the entire olfactory bulb.
Discovered a correlation between olfactory receptor sequence and its specific glomerular position within the OB.

Conclusions:

The developed method enables comprehensive spatial mapping of ORs in the OB.
Revealed an underlying organizational principle in the olfactory system relating OR sequence to spatial organization.