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A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation
Published on: December 9, 2021
Inflammation propagation modeled as a reaction-diffusion wave
W El Hajj1, N El Khatib2, V Volpert3
1Institut Camille Jordan, UMR 5208 CNRS, University Lyon 1, 69622 Villeurbanne, France.
None:
Inflammation is a physiological process aimed to protect the organism in various diseases and injuries. This work presents a generic inflammation model based on the reaction-diffusion equations for the concentrations of uninflamed cells, inflamed cells, immune cells and the inflammatory cytokines. The analysis of the model shows the existence of three different regimes of inflammation progression depending on the value of a parameter R called the inflammation number. If R>1, then inflammation propagates in cell culture or tissue as a reaction-diffusion wave due to diffusion of inflammatory cytokines produced by inflamed cells. If 0
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