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Measurement of Tactile Allodynia in a Murine Model of Bacterial Prostatitis
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CEACAM expression in an in-vitro prostatitis model.

Irina Kube-Golovin1, Mykola Lyndin1,2, Marc Wiesehöfer1

  • 1University Hospital Essen, Department of Anatomy, Essen, Germany.

Frontiers in Immunology
|September 11, 2023
PubMed
Summary
This summary is machine-generated.

Pro-inflammatory cytokines upregulate CEACAM1-L in prostate cells, linking inflammation to potential prostate cancer (PCa) development. This CEACAM1 isoform may drive inflammation-induced oncogenesis.

Keywords:
CEACAMCEACAM1inflammationprostate cancerprostatitis

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Area of Science:

  • Cell Biology
  • Oncology
  • Inflammation Research

Background:

  • Prostatitis affects 2-16% of men globally and may contribute to prostate cancer (PCa).
  • Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) are implicated in inflammation and PCa, but their role in prostate inflammation and malignant transformation is unclear.

Purpose of the Study:

  • To investigate CEACAM expression in an in-vitro prostatitis model.
  • To explore the role of CEACAMs in the malignant transformation of prostate epithelial cells.

Main Methods:

  • Normal prostate epithelial RWPE-1 cells were induced into an inflammatory state using pro-inflammatory cytokines (TNFα and IFNγ).
  • CEACAM expression and isoforms were analyzed.
  • CEACAM expression was correlated with malignancy markers and cell migration.

Main Results:

  • Tumor necrosis factor alpha (TNFα) and interferon-gamma (IFNγ) synergistically up-regulated CEACAM1 expression, particularly the CEACAM1-L isoform, in RWPE-1 cells.
  • Overexpressed CEACAM1-L correlated with altered JAK/STAT and NFκB signaling pathways.
  • CEACAM1-L overexpression was associated with genes involved in epithelial-mesenchymal transition (EMT) and increased cell migration.

Conclusions:

  • The CEACAM1 isoform CEACAM1-4L may play a synergistic role in inflammation-induced prostate oncogenesis.
  • Understanding CEACAM1's role in prostatitis could offer new insights into PCa development.