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Updated: Jul 16, 2025

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
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Decoding m6A mRNA methylation by reader proteins in liver diseases.

Lijiao Sun1,2,3, Xin Chen1,2,3, Sai Zhu1,4

  • 1Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, China.

Genes & Diseases
|September 11, 2023
PubMed
Summary

N6-methyladenosine (m6A) regulates gene expression via reader proteins. This review explores m6A reader roles in liver diseases like cancer and hepatitis, highlighting their pathogenic mechanisms and therapeutic potential.

Keywords:
IGF2BPsLiver diseasesYTH domain proteinm6A modificationm6A readermRNA metabolism

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Area of Science:

  • Epigenetics
  • Molecular Biology
  • Hepatology

Background:

  • N6-methyladenosine (m6A) is the most abundant internal RNA modification in eukaryotes.
  • m6A regulates gene expression through mRNA splicing, stability, translation, and localization.
  • m6A modification requires reader proteins for recognition and downstream effects.

Purpose of the Study:

  • To introduce m6A readers and their regulatory mechanisms.
  • To summarize the biological functions and mechanisms of m6A readers in various liver diseases.
  • To provide insights into the links between m6A readers and human liver diseases.

Main Methods:

  • Literature review focusing on m6A readers in liver disease pathogenesis.
  • Analysis of m6A reader recognition and regulatory mechanisms on mRNA.
  • Synthesis of current research on m6A readers in liver cancer, viral hepatitis, NAFLD, HF, and ALI.

Main Results:

  • m6A readers play critical roles in regulating gene expression relevant to liver disease.
  • Abnormal expression of m6A readers influences the fate of gene transcripts in liver pathologies.
  • Specific m6A readers are implicated in the development and progression of diverse liver conditions.

Conclusions:

  • m6A readers are key mediators in the molecular pathways of liver diseases.
  • Understanding m6A reader functions offers potential therapeutic targets for liver disease treatment.
  • This review highlights the significant impact of m6A readers on liver health and disease.