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Updated: Jul 16, 2025

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
08:56

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

Published on: December 5, 2016

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Decoding m6A mRNA methylation by reader proteins in liver diseases

Lijiao Sun1,2,3, Xin Chen1,2,3, Sai Zhu1,4

  • 1Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, China.

Genes & Diseases
|September 11, 2023
PubMed

Insights

N6-methyladenosine (m6A) regulates gene expression via reader proteins. This review explores m6A reader roles in liver diseases like cancer and hepatitis, highlighting their pathogenic mechanisms and therapeutic potential.

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Hepatology

Background:

  • N6-methyladenosine (m6A) is the most abundant internal RNA modification in eukaryotes.
  • m6A regulates gene expression through mRNA splicing, stability, translation, and localization.
  • m6A modification requires reader proteins for recognition and downstream effects.

Purpose of the Study:

  • To introduce m6A readers and their regulatory mechanisms.
  • To summarize the biological functions and mechanisms of m6A readers in various liver diseases.
  • To provide insights into the links between m6A readers and human liver diseases.

Main Methods:

  • Literature review focusing on m6A readers in liver disease pathogenesis.
  • Analysis of m6A reader recognition and regulatory mechanisms on mRNA.
  • Synthesis of current research on m6A readers in liver cancer, viral hepatitis, NAFLD, HF, and ALI.

Main Results:

  • m6A readers play critical roles in regulating gene expression relevant to liver disease.
  • Abnormal expression of m6A readers influences the fate of gene transcripts in liver pathologies.
  • Specific m6A readers are implicated in the development and progression of diverse liver conditions.

Conclusions:

  • m6A readers are key mediators in the molecular pathways of liver diseases.
  • Understanding m6A reader functions offers potential therapeutic targets for liver disease treatment.
  • This review highlights the significant impact of m6A readers on liver health and disease.
Keywords:
IGF2BPsLiver diseasesYTH domain proteinm6A modificationm6A readermRNA metabolism

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