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Flourishing tumor organoids: History, emerging technology, and application
Qian Yang1, Mengmeng Li1, Xinming Yang1
1Department of Otorhinolaryngology Head and Neck Surgery, the Second Xiangya Hospital Central South University Changsha Hunan China.
Bioengineering & Translational Medicine
|September 11, 2023
Summary
Tumor organoids, 3D models mimicking patient tumors, are revolutionizing cancer research. They enhance drug development, precision medicine, and understanding of tumor mechanisms.
Area of Science:
- Oncology
- Biotechnology
- Regenerative Medicine
Background:
- Malignant tumors are a leading cause of death globally.
- Accurate tumor research models are vital for understanding cancer, developing drugs, and personalizing treatments.
Purpose of the Study:
- To review the history, characteristics, and applications of tumor organoids in cancer research.
- To explore the integration of tumor organoids with emerging technologies.
Main Methods:
- Review of existing literature on tumor organoid development and applications.
- Discussion of synergistic combinations with technologies like 3D bioprinting and CRISPR-Cas9.
Main Results:
- Organoids preserve tumor structure, heterogeneity, and function, facilitating research.
- Applications span mechanism studies, drug screening, precision medicine, and immunotherapy.
Conclusions:
- Tumor organoids offer significant advantages for basic and clinical cancer research.
- Future directions include addressing current limitations and further technological integration.
