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Related Concept Videos

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

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The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
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Related Experiment Video

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Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
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Enzyme-responsive macrocyclic metal complexes for biomedical imaging.

Quoc-Viet Le1, Jaiwoo Lee2, Seungbeom Ko2

  • 1Faculty of Pharmacy Ton Duc Thang University Ho Chi Minh City Vietnam.

Bioengineering & Translational Medicine
|September 11, 2023
PubMed
Summary
This summary is machine-generated.

This study introduces a novel enzyme-responsive gadolinium (Gd) delivery system for enhanced cancer imaging. The system improves MRI contrast agent safety and tumor specificity, showing promise for theranostic applications.

Keywords:
biomedical imagingcontrast agentmacrocyclammetal ion

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Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Radiochemistry

Background:

  • Metal chelator contrast agents are crucial for cancer diagnosis via MRI.
  • Current agents require high doses due to rapid clearance and non-specific accumulation, posing safety concerns.

Purpose of the Study:

  • To develop an enzyme-responsive metal delivery system for targeted gadolinium (Gd) uptake in tumors.
  • To enhance the safety and specificity of MRI contrast agents.

Main Methods:

  • A gadolinium-loaded enzyme-responsive macrocyclam (Gd@ErMC) was engineered with a PEGylated, enzyme-cleavable peptide.
  • In vivo studies in tumor-bearing mice utilized MRI and positron emission tomography (PET) for distribution analysis.
  • Histological and serological analyses were performed to assess safety.

Main Results:

  • Gd@ErMC demonstrated an extended half-life and high tumor specificity.
  • The PEGylated shell protected against non-specific binding, while enzyme cleavage at the tumor site selectively released Gd.
  • Safety assessments confirmed the agent's low toxicity.

Conclusions:

  • The novel enzyme-responsive contrast agent delivery system enhances tumor targeting and safety.
  • This system shows potential as a theranostic agent for MR-guided radiotherapy.