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Updated: Jul 16, 2025

Inducible and Reversible Dominant-negative DN Protein Inhibition
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PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression

Christin Schmidt, Sarah Cohen, Brian L Gudenas

    Biorxiv : the Preprint Server for Biology
    |September 11, 2023
    PubMed
    Summary

    PRDM6 expression promotes medulloblastoma but does not exclusively drive Group 4. Additional factors are needed for Group 4 medulloblastoma development, suggesting PRDM6 inhibition as a potential therapy.

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