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Aging Rate Indicators: Speedometers for Aging Research in Mice.
Richard A Miller1, Xinna Li1, Gonzalo Garcia1
1Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, USA.
Aging Biology
|September 11, 2023
Summary
Aging rate indicators (ARIs) measure the speed of aging, unlike biomarkers of aging. Common ARIs were identified in slow-aging mice, suggesting potential targets for interventions against age-related diseases.
Area of Science:
- Gerontology
- Molecular Biology
- Physiology
Background:
- Biomarkers of aging track aging progress, while aging rate indicators (ARIs) measure the speed of aging.
- Understanding ARIs is crucial for developing interventions to slow aging and combat age-related diseases.
Purpose of the Study:
- To review data on common characteristics of slow-aging mice.
- To identify candidate aging rate indicators (ARIs) shared across different aging deceleration methods.
Main Methods:
- Review of recent data on slow-aging mice induced by genetic mutation, calorie restriction, or drugs.
- Analysis of physiological and molecular changes in various tissues and cellular pathways.
Main Results:
- Nine varieties of slow-aging mice exhibited shared ARIs in fat, muscle, liver, brain, and plasma.
- Molecular ARIs included mTORC1 activity, mRNA translation, and MAPK signaling pathways.
- These changes were detectable early in life and persisted, influencing cognition, inflammation, and metabolism.
Conclusions:
- Candidate ARIs are plausible modulators of age-related physiological and neurological conditions.
- Screening for drugs that alter ARIs in young mice may accelerate the discovery of anti-aging interventions.
