Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nitric Oxide Signaling Pathway

Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Localized Nitric Oxide Release from a Ciprofloxacin Hybrid Conjugate Enables Potent Disruption of Gram-Positive and Gram-Negative Biofilms.

ACS applied bio materials·2026

Same author

Reactive Multifunctional Ink for Hydrogel Fabrication and Cell-Laden 3D Printing via Incorporation of Strontium-Doped Bioactive Glass.

ACS applied bio materials·2026

Same author

Development of drug-loaded MnO<sub>2</sub> nanoflowers on nitric oxide-releasing polymer platforms for antimicrobial and antifungal applications.

Journal of colloid and interface science·2026

Same author

Sustained nitric oxide-releasing aliphatic lubricants: Infusion in polymers for enhanced slippery and antibacterial efficacy.

Biomaterials advances·2026

Same author

Exploring the Versatility of Multifunctional Additives for PMMA-Based Bone Cements to Improve Clinical Performance: An Update.

ACS applied bio materials·2026

Same author

Engineering a dual-action nitric oxide and propolis releasing polymeric matrix for extended antimicrobial efficacy.

Journal of materials chemistry. B·2026

Search research articles

Related Experiment Video

Updated: Jul 16, 2025

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

Advances in Nitric Oxide-Releasing Hydrogels for Biomedical Applications.

Lori M Estes Bright¹, Yi Wu¹, Elizabeth J Brisbois¹

¹School of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, GA, USA.

Current Opinion in Colloid & Interface Science

|September 11, 2023

Summary

Nitric oxide (NO)-releasing hydrogels offer versatile biomaterials for advanced medical treatments. These NO-releasing hydrogels show promise in cardiovascular therapy, wound healing, and regenerative medicine.

Keywords:

antimicrobial biomedical hydrogels nitric oxide wound healing

More Related Videos

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Related Experiment Videos

Last Updated: Jul 16, 2025

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Synthesis of Strong Adhesive Hydrogel, Gelatin O-Nitrosobenzaldehyde

Published on: November 11, 2022

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Area of Science:

Biomaterials Science
Regenerative Medicine
Drug Delivery Systems

Background:

Hydrogels possess advantageous hydrophilic and mechanical properties for biomedical applications.
Nitric oxide (NO) plays crucial endogenous roles, driving research into NO-delivery biomaterials.
Existing challenges in biomedicine necessitate innovative biomimetic solutions.

Purpose of the Study:

To present an in-depth update on the progress of nitric oxide (NO)-releasing hydrogels.
To discuss design and fabrication considerations for NO-releasing hydrogels.
To explore specific biomedical applications of these advanced hydrogel systems.

Main Methods:

Review of recent advancements in NO-releasing hydrogel technology.
Analysis of design parameters influencing hydrogel performance.
Examination of fabrication techniques for NO-releasing hydrogels.

Main Results:

NO-releasing hydrogels demonstrate significant potential across diverse biomedical fields.
Key applications include cardiovascular therapies, promoting vasodilation and angiogenesis.
Further uses span antimicrobial treatments, advanced wound dressings, and stem cell research.

Conclusions:

NO-releasing hydrogels represent a promising class of biomaterials for therapeutic interventions.
Careful consideration of design and fabrication is crucial for optimizing hydrogel function.
These materials offer innovative solutions for numerous unmet medical needs.