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Articles linked to this work by shared authors, journal, and citation graph.

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Related Experiment Video

Updated: Jul 16, 2025

Performing Intracochlear Electrocochleography During Cochlear Implantation
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Intra-cochlear Flushing Reduces Tissue Response to Cochlear Implantation.

Tayla Razmovski1, Kate M Brody1, Dimitra Stathopoulos1

  • 1Otolaryngology, Department of Surgery, Royal Victorian Eye and Ear Hospital, University of Melbourne, East Melbourne, Victoria, Australia.

The Laryngoscope
|September 11, 2023
PubMed
Summary

Flushing blood from the cochlea during surgery improved hearing outcomes and reduced fibrosis in guinea pigs. This study supports implementing an intra-cochlear flushing protocol for cochlear implantation.

Keywords:
cochlear implantationintra-cochlear traumalight sheet microscopytherapeutic interventiontissue response

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Related Experiment Videos

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Area of Science:

  • Oto-neurology
  • Surgical Innovation
  • Regenerative Medicine

Background:

  • Intraoperative bleeding during cochlear implantation can harm residual hearing.
  • Current clinical practices lack protocols for intra-cochlear blood removal.
  • Blood in the cochlea can cause inflammation and fibrosis, impacting cochlear health.

Purpose of the Study:

  • To investigate the efficacy of an intra-cochlear flushing protocol for blood removal.
  • To assess the impact of blood removal on auditory function and cochlear tissue response.
  • To evaluate the potential for a new clinical protocol in cochlear implantation.

Main Methods:

  • A preclinical study involving guinea pigs with cochlear implants.
  • Three groups were used: control (implant only), blood injection, and blood injection with intraoperative flushing.
  • Auditory brainstem responses (ABRs) and tissue response volumes were analyzed over 28 days.

Main Results:

  • The blood group showed significantly higher ABR thresholds, especially at high frequencies.
  • The flush group exhibited the lowest ABR thresholds, significantly better at 24 kHz.
  • The flush group demonstrated reduced tissue response in the basal cochlear region.

Conclusions:

  • Intra-cochlear flushing effectively removes blood, improving auditory function post-implantation.
  • This protocol significantly reduces fibrosis in the basal cochlea.
  • Findings support the clinical implementation of an intra-cochlear flushing protocol during cochlear implantation.